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PURUHOOTHIKA SOFTCONDUCTOR SERVICES HEVS CORPORATION.
DRUGS & VACCINATIONS DISCOVERY & DEVELOPING BY USING THE
ARTIFICIAL INTELLIGENCE(AI) & QUANTUM COMPUTING TECHNOLOGIES.
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CHOLINERGICS
AntiCholinesterases Inhibit the Enzyme AcetylCholinesterases and have Same Clinical Effects
as Cholinergicagonists.
The Active site for AcetylCholinesterases is similar to the Binding Site
for the Cholinergic Receptor, but also Includes the Amino Acids
Histidine and Serine.
NeuroMuscular Blocking Activity for Tubocurarine is Associated with a Pharmacophore, where
the Distance between
the Two Charged Nitrogen Atoms is 1.15 nm. Octamethonium is an Analogue of
Decamethonium, and contains an Eight - Carbon Bridge
between the charged Nitrogen Atoms.
The most stable conformation for this Structure is the Fully Extended One.
Where the N - N Distance is 1.157 nm.Where as Octamethonium is likely to be more active than Decamethonium.
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